Chromosome errors in human eggs shape natural fertility over reproductive lifespan

Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions causing pregnancy loss and congenital disorders. Here we have followed chromosome segregation in human oocytes from females aged 9 to 43 years, and report that aneuploidy follows a U-curve. Specific segregatio...

詳細記述

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書誌詳細
出版年:Science
主要な著者: Gruhn, Jennifer R., Zielinska, Agata P., Shukla, Vallari, Blanshard, Robert, Capalbo, Antonio, Cimadomo, Danilo, Nikiforov, Dmitry, Chan, Andrew Chi-Ho, Newnham, Louise J., Vogel, Ivan, Scarica, Catello, Krapchev, Marta, Taylor, Deborah, Kristensen, Stine Gry, Cheng, Junping, Ernst, Erik, Bjørn, Anne-Mette Bay, Colmorn, Lotte Berdiin, Blayney, Martyn, Elder, Kay, Liss, Joanna, Hartshorne, Geraldine, Groendahl, Marie Louise, Rienzi, Laura, Ubaldi, Filippo, McCoy, Rajiv, Lukaszuk, Krzysztof, Andersen, Claus Yding, Schuh, Melina, Hoffmann, Eva R.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212007/
https://ncbi.nlm.nih.gov/pubmed/31604276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav7321
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