Design, synthesis, molecular modelling and in vitro screening of monoamine oxidase inhibitory activities of novel quinazolyl hydrazine derivatives

A new series of N'-substituted benzylidene-2-(4-oxo-2-phenyl-1,4-dihydroquinazolin-3(2H)-yl)acetohydrazide (5a–5h) has been synthesized, characterized by FT-IR, NMR spectroscopy and mass spectrometry and tested against human monoamine oxidase (MAO) A and B. Only (4-hydroxy-3-methoxybenzylidene)...

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Detalhes bibliográficos
Publicado no:R Soc Open Sci
Main Authors: Amer, Adel, Hegazi, Abdelrahman H., Alshekh, Mohammed Khalil, Ahmed, Hany E. A., Soliman, Saied M., Maniquet, Antonin, Ramsay, Rona R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2020
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7211837/
https://ncbi.nlm.nih.gov/pubmed/32431898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.200050
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