Oncolytic Adenovirus Armed with BiTE, Cytokine, and Checkpoint Inhibitor Enables CAR T Cells to Control the Growth of Heterogeneous Tumors

No single cancer immunotherapy will likely defeat all evasion mechanisms of solid tumors, including plasticity of tumor antigen expression and active immune suppression by the tumor environment. In this study, we increase the breadth, potency, and duration of anti-tumor activity of chimeric antigen...

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Pubblicato in:Mol Ther
Autori principali: Porter, Caroline E., Rosewell Shaw, Amanda, Jung, Youngrock, Yip, Tiffany, Castro, Patricia D., Sandulache, Vlad C., Sikora, Andrew, Gottschalk, Stephen, Ittman, Michael M., Brenner, Malcolm K., Suzuki, Masataka
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210703/
https://ncbi.nlm.nih.gov/pubmed/32145203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.02.016
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