Oncolytic Adenovirus Armed with BiTE, Cytokine, and Checkpoint Inhibitor Enables CAR T Cells to Control the Growth of Heterogeneous Tumors

No single cancer immunotherapy will likely defeat all evasion mechanisms of solid tumors, including plasticity of tumor antigen expression and active immune suppression by the tumor environment. In this study, we increase the breadth, potency, and duration of anti-tumor activity of chimeric antigen...

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Vydáno v:Mol Ther
Hlavní autoři: Porter, Caroline E., Rosewell Shaw, Amanda, Jung, Youngrock, Yip, Tiffany, Castro, Patricia D., Sandulache, Vlad C., Sikora, Andrew, Gottschalk, Stephen, Ittman, Michael M., Brenner, Malcolm K., Suzuki, Masataka
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2020
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210703/
https://ncbi.nlm.nih.gov/pubmed/32145203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.02.016
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