Maternal high-fat diet exaggerates diet-induced insulin resistance in adult offspring by enhancing inflammasome activation through noncanonical pathway of caspase-11

OBJECTIVE: Maternal high-fat diet (HFD) has been shown to promote the development of insulin resistance (IR) in adult offspring; however, the underlying mechanisms remain unclear. METHODS: Eight-week-old female wild-type mice (C57BL/6) were fed either an HFD or a normal diet (ND), one week prior to...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Wada, Naotoshi, Yamada, Hiroyuki, Motoyama, Shinichiro, Saburi, Makoto, Sugimoto, Takeshi, Kubota, Hiroshi, Miyawaki, Daisuke, Wakana, Noriyuki, Kami, Daisuke, Ogata, Takehiro, Matoba, Satoaki
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210595/
https://ncbi.nlm.nih.gov/pubmed/32272237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.100988
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