Poly(Beta-Amino Ester) Nanoparticles Enable Nonviral Delivery of CRISPR-Cas9 Plasmids for Gene Knockout and Gene Deletion

The CRISPR-Cas9 system is a powerful gene-editing tool with wide-ranging applications, but the safe and efficient intracellular delivery of CRISPR components remains a challenge. In this study, we utilized biodegradable poly(beta-amino ester) nanoparticles to codeliver plasmid DNA encoding Cas9 and...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Rui, Yuan, Varanasi, Mahita, Mendes, Shanelle, Yamagata, Hannah M., Wilson, David R., Green, Jordan J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210380/
https://ncbi.nlm.nih.gov/pubmed/32380416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.04.005
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