SUN-662 Praliciguat, a Clinical-Stage Soluble Guanylate Cyclase Stimulator, Improves Lipid Handling and Insulin Sensitivity in Diet-Induced Obese Mice

Praliciguat (PRL) is a soluble guanylate cyclase (sGC) stimulator which in animal models distributes broadly to tissues and elicits hemodynamic, anti-inflammatory, anti-fibrotic, and metabolic effects. Here, we assessed metabolic effects of PRL in a mouse diet-induced obesity model. Six-week-old mal...

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Veröffentlicht in:J Endocr Soc
Hauptverfasser: Schwartzkopf, Chad D, Liu, Guang, Hadcock, John R, Currie, Mark G, Masferrer, Jamie L, Jones, Juli E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Diabetes Mellitus and Glucose Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7209036/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.917
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