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Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats
The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [(14)C]praliciguat were evaluated following oral administration of a 3‐mg/kg dose in Sprague‐Dawley rats and in a quantitative whole‐body autoradiography (QWBA) study conducted in male Long‐Evans rats. Plasma...
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| Publié dans: | Pharmacol Res Perspect |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7171252/ https://ncbi.nlm.nih.gov/pubmed/32314550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.579 |
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