SUN-LB124 Novel Elisa Assays Demonstrate Specificity of Islet and Intestinal Processing of Proglucagon

Circulating proglucagon peptides (PGP) are produced in islet α-cells, enteroendocrine L-cells. Release of PGP is thought to be tissue specific, e.g. α-cells make glucagon and L-cells make GLP-1 through predominant actions of proconvertases 2 and 1/3 (PC2 and PC1/3). However, this dichotomous model h...

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Vydáno v:J Endocr Soc
Hlavní autoři: D’Alessio, David A, Kumar, Ajay, Kalra, Bhanu, Mistry, Shivani, Tong, Jenny
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Diabetes Mellitus and Glucose Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7209030/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.2330
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