SUN-739 Next Generation AR Antagonists Increase Systemic Active Glucocorticoid Exposure by Altering Glucocorticoid Metabolism

Enzalutamide and apalutamide are potent next-generation androgen receptor (AR) antagonists used in metastatic and non-metastatic prostate cancer. Despite the increased survival benefits of these agents, resistance normally occurs and the disease transitions to its lethal form. We hypothesized that e...

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Vydáno v:J Endocr Soc
Hlavní autoři: Alyamani, Mohammad, Sharifi, Nima, Li, Jianbo, Patel, Mona, Berk, Michael, Taylor, Susan, Przybycin, Christopher, Posadas, Edwin M, Madan, Ravi, Gulley, James L, Rini, Brian I, Garcia, Jorgi A, Klein, Eric A
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Steroid Hormones and Receptors
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208944/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1762
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