SAT-308 Effect of Silibinin on ACTH Synthesis and Secretion in Human Adenomatous Corticotropes in Vitro

Silibinin, a milk thistle extract with known hepatoprotective effects, has recently been shown to act upon tumoral corticotropes and revert the Cushingoid phenotype in an allograft mouse model (Riebold et al 2015). Silbinin is known to inhibit HSP90 -a chaperone to the glucocorticoid receptor- there...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Cassarino, Maria Francesca, Sesta, Antonella, Libera, Laura, Bardelli, Donatella, Losa, Marco, Lasio, Giovanni, Giraldi, Francesca Pecori
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Neuroendocrinology and Pituitary
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208688/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.417
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