Ubiquitin-Specific Protease 8 Mutant Corticotrope Adenomas Present Unique Secretory and Molecular Features and Shed Light on the Role of Ubiquitylation on ACTH Processing

BACKGROUND: Somatic mutations in the ubiquitin-specific protease 8 (USP8) gene have recently been shown to occur in ACTH-secreting pituitary adenomas, thus calling attention to the ubiquitin system in corticotrope adenomas. OBJECTIVES: Assess the consequences of USP8 mutations and establish the role...

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Detalhes bibliográficos
Publicado no:Neuroendocrinology
Main Authors: Sesta, Antonella, Cassarino, Maria Francesca, Terreni, Mariarosa, Ambrogio, Alberto G., Libera, Laura, Bardelli, Donatella, Lasio, Giovanni, Losa, Marco, Pecori Giraldi, Francesca
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6979434/
https://ncbi.nlm.nih.gov/pubmed/31280266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000500688
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