SAT-LB97 MiRNA-99a and mTOR2 Mediate Enhanced Endothelial Mineralocorticoid Receptor Signaling-Induced Activation of Sodium Channel and Endothelium Stiffness

In diet induced obesity enhanced endothelial cell (EC) mineralocorticoid receptor (MR) (ECMR) and downstream sodium channel (EnNaC) activity increases oxidative stress and inflammation, thereby promoting vascular stiffness and associated impaired endothelial mediated relaxation. For example, consump...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Jia, Guanghong, Aroor, Annayya R, Habibi, Javad, Yang, Yan, DeMarco, Vincent G, Hill, Michael A, Whaley-Connell, Adam T, Jaisser, Frederic, Jaffe, Iris Zamir, Sowers, James R
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Cardiovascular Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208520/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1987
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