SAT-LB101 Loss of GLP-2R Signaling Activates Hepatic Stellate Cells and Exacerbates Diet-Induced Steatohepatitis in Mice

A GLP-2 analogue is used in individuals with intestinal failure at risk for liver disease, yet the hepatic actions of GLP-2 are not understood. Treatment of high fat diet (HFD)-fed mice with GLP-2 did not modify the development of hepatosteatosis or hepatic inflammation. In contrast, Glp2r(-/-) mice...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Fuchs, Shai Z, Yusta, Bernardo, Baggio, Laurie, Varin, Elodie, Matthews, Dianne, Drucker, Daniel J
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Adipose Tissue, Appetite, and Obesity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208342/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.2181
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