OR05-01 Small Heterodimer Partner Modulates Antigen Presenting Myeloid Cells to Impair Regulatory T Cell Expansion, Promoting Anti-Tumor Immunity in Models of Breast Cancer

Immune checkpoint blockade has had underwhelming responses in breast cancer, in part due to the highly immune suppressive microenvironment. As a result, breast cancer continues to be the second most common cancer-related mortality amongst women, providing strong rationale for the development of new...

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Veröffentlicht in:J Endocr Soc
Hauptverfasser: Shahoei, Sayyed Hamed, Nelson, Adam T, Henn, Madeline A, Mathews, Ashley E, Chen, Joy J, Vembar, Varsha, Vardanyan, Anna, Ma, Liqian, Wang, Yu, Apetoh, Lionel, Nelson, Erik Russell
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Tumor Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208157/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1056
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