OR24-03 GRK2 Mediates Beta-Adrenergic Receptor Crosstalk to Enhanced Adrenocortical AngII-Dependent Aldosterone Production

Aldosterone is produced by adrenocortical zona glomerulosa (AZG) cells in response to hyperkalemia or angiotensin II (AngII) acting through its type I receptors (AT(1)Rs). AT(1)R is a G protein-coupled receptor (GPCR) that induces aldosterone synthesis and secretion via both G proteins and the GPCR...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Lymperopoulos, Anastasios, Pollard, Celina M, Pereyra, Janelle M, Desimine, Victoria L, Wertz, Shelby L, Perez, Arianna, Ferraino, Krysten E, Cora, Natalie
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Genetics and Development (including Gene Regulation)
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208074/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.047
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