SAT-133 Breast Tumor Kinase (Brk/PTK6) Mediates Triple Negative Breast Cancer Cell Migration and Taxol Resistance via SH2 Domain-Dependent Activation of RhoA and AhR

Triple negative breast cancer (TNBC) patients have higher recurrence rates and a worse prognosis relative to patients diagnosed with other breast cancer subtypes. Protein tyrosine kinase 6 (PTK6; also called Brk), a soluble tyrosine kinase, is overexpressed in 86% of breast cancer patients, however...

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Vydáno v:J Endocr Soc
Hlavní autoři: Dwyer, Amy Renee, Kerkvliet, Carlos J Perez, Krutilina, Raisa, Playa, Hilaire, Park, Deanna, Thomas, Warner, Smeester, Branden, Seagroves, Tiffany Nicole, Lange, Carol A
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Tumor Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7207976/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1750
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