OR28-01 Constitutive Activation of NRF2 Antioxidant Response Leads to Age-Dependent Goiter and Compensated Hypothyroidism in Male Mice

Background: Familial non-toxic multinodular goiter (MNG) is a rare disease. KEAP1 gene (Kelch-like ECH-associated protein 1) that encodes the main inhibitor of nuclear factor erythroid 2-related transcription factor 2 (Nrf2), a central mediator of antioxidant responses, has been found to be one of t...

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Publicado en:J Endocr Soc
Autores principales: Chartoumpekis, Dionysios, Ziros, Panos, Renaud, Cédric, Bongiovanni, Massimo, Habeos, Ioannis, Liao, Xiao-Hui, Refetoff, Samuel, Kopp, Peter, Brix, Klaudia, Sykiotis, Gerasimos
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Thyroid
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7207596/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.2042
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