SAT-144 Cooperative Mechanism of SREBP-Dependent Cholesterol Synthesis Pathway and P53 on Malignant Formation in Breast Cancer

p53 is mutated more than half of human cancers, and mutant p53, a gain of function, can actively have functional consequences with tumorigenesis. However, its action of molecular mechanisms, particularly in vivo conditions, has not been fully are clarified. Here, we generated KO and KI (R280K) breas...

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Dades bibliogràfiques
Publicat a:J Endocr Soc
Autors principals: Nakayama, Akitoshi, Yokoyama, Masataka, Nagano, Hidekazu, Sakuma, Ikki, Hashimoto, Naoko, Higuchi, Seiichiro, Yamagata, Kazuyuki, Tanaka, Tomoaki
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Tumor Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7207476/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1670
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