Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by protein inclusions mostly composed of aggregated forms of α-synuclein (α-Syn) and by the progressive degeneration of midbrain dopaminergic neurons (mDANs), resulting in motor symptoms. While other brain regions also undergo pa...

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Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Brazdis, Razvan-Marius, Alecu, Julian E, Marsch, Daniel, Dahms, Annika, Simmnacher, Katrin, Lörentz, Sandra, Brendler, Anna, Schneider, Yanni, Marxreiter, Franz, Roybon, Laurent, Winner, Beate, Xiang, Wei, Prots, Iryna
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206857/
https://ncbi.nlm.nih.gov/pubmed/32160287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa039
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