DNA methylation QTL analysis identifies new regulators of human longevity

Human longevity is a complex trait influenced by both genetic and environmental factors, whose interaction is mediated by epigenetic mechanisms like DNA methylation. Here, we generated genome-wide whole-blood methylome data from 267 individuals, of which 71 were long-lived (90–104 years), by applyin...

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Publicat a:Hum Mol Genet
Autors principals: Szymczak, Silke, Dose, Janina, Torres, Guillermo G, Heinsen, Femke-Anouska, Venkatesh, Geetha, Datlinger, Paul, Nygaard, Marianne, Mengel-From, Jonas, Flachsbart, Friederike, Klapper, Wolfram, Christensen, Kaare, Lieb, Wolfgang, Schreiber, Stefan, Häsler, Robert, Bock, Christoph, Franke, Andre, Nebel, Almut
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
General Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206852/
https://ncbi.nlm.nih.gov/pubmed/32160291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa033
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