Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats

BACKGROUND: The disruption of the blood–brain barrier (BBB) plays a critical event in the pathogenesis of ischemia stroke. TGR5 is recognized as a potential target for the treatment for neurologic disorders. METHODS: This study investigated the roles of TGR5 activation in attenuating BBB damage and...

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Detalhes bibliográficos
Publicado no:J Biomed Sci
Main Authors: Liang, Hui, Matei, Nate, McBride, Devin W., Xu, Yang, Tang, Jiping, Luo, Benyan, Zhang, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206796/
https://ncbi.nlm.nih.gov/pubmed/32381096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-020-00656-9
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