TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

BACKGROUND: Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) plays an important role in mediating inflammatory responses during ischemic stroke. Bile acid receptor Takeda-G-protein-receptor-5 (TGR5) has been identified as an important component in reg...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Liang, Hui, Matei, Nathanael, McBride, Devin W., Xu, Yang, Zhou, Zhenhua, Tang, Jiping, Luo, Benyan, Zhang, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856773/
https://ncbi.nlm.nih.gov/pubmed/33531049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02087-1
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