Application of droplet digital PCR for the detection of vector copy number in clinical CAR/TCR T cell products

BACKGROUND: Genetically engineered T cells have become an important therapy for B-cell malignancies. Measuring the efficiency of vector integration into the T cell genome is important for assessing the potency and safety of these cancer immunotherapies. METHODS: A digital droplet polymerase chain re...

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Detalles Bibliográficos
Publicado en:J Transl Med
Main Authors: Lu, Alex, Liu, Hui, Shi, Rongye, Cai, Yihua, Ma, Jinxia, Shao, Lipei, Rong, Victor, Gkitsas, Nikolaos, Lei, Hong, Highfill, Steven L., Panch, Sandhya, Stroncek, David F., Jin, Ping
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206671/
https://ncbi.nlm.nih.gov/pubmed/32384903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02358-0
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