CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases

The cullin-RING ubiquitin E3 ligase (CRL) family consists of ~250 complexes that catalyze ubiquitylation of proteins to achieve cellular regulation. All CRLs are inhibited by the COP9 signalosome complex (CSN) through both enzymatic (deneddylation) and nonenzymatic (steric) mechanisms. The relative...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Füzesi-Levi, Maria G., Fainer, Irit, Ivanov Enchev, Radoslav, Ben-Nissan, Gili, Levin, Yishai, Kupervaser, Meital, Friedlander, Gilgi, Salame, Tomer Meir, Nevo, Reinat, Peter, Matthias, Sharon, Michal
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206152/
https://ncbi.nlm.nih.gov/pubmed/31367012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0392-8
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