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Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
Heterozygous mutations of the lysosomal enzyme glucocerebrosidase (GBA1) represent the major genetic risk for Parkinson’s disease (PD), while homozygous GBA1 mutations cause Gaucher disease, a lysosomal storage disorder, which may involve severe neurodegeneration. We have previously demonstrated imp...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Cell Death Differ |
|---|---|
| Prif Awduron: | , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Nature Publishing Group UK
2019
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7206133/ https://ncbi.nlm.nih.gov/pubmed/31685979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0442-2 |
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