Cumulative inactivation of Nell-1 in Wnt1 expressing cell lineages results in craniofacial skeletal hypoplasia and postnatal hydrocephalus

Upregulation of Nell-1 has been associated with craniosynostosis (CS) in humans, and validated in a mouse transgenic Nell-1 overexpression model. Global Nell-1 inactivation in mice by N-ethyl-N-nitrosourea (ENU) mutagenesis results in neonatal lethality with skeletal abnormalities including cleidocr...

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Bibliografski detalji
Izdano u:Cell Death Differ
Glavni autori: Chen, Xiaoyan, Wang, Huiming, Yu, Mengliu, Kim, Jong Kil, Qi, Huichuan, Ha, Pin, Jiang, Wenlu, Chen, Eric, Luo, Xiangyou, Needle, Ryan Brent, Baik, Lloyd, Yang, Cathryn, Shi, Jiejun, Kwak, Jin Hee, Ting, Kang, Zhang, Xinli, Soo, Chia
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206096/
https://ncbi.nlm.nih.gov/pubmed/31582804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0427-1
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