Cumulative inactivation of Nell-1 in Wnt1 expressing cell lineages results in craniofacial skeletal hypoplasia and postnatal hydrocephalus

Upregulation of Nell-1 has been associated with craniosynostosis (CS) in humans, and validated in a mouse transgenic Nell-1 overexpression model. Global Nell-1 inactivation in mice by N-ethyl-N-nitrosourea (ENU) mutagenesis results in neonatal lethality with skeletal abnormalities including cleidocr...

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Udgivet i:Cell Death Differ
Main Authors: Chen, Xiaoyan, Wang, Huiming, Yu, Mengliu, Kim, Jong Kil, Qi, Huichuan, Ha, Pin, Jiang, Wenlu, Chen, Eric, Luo, Xiangyou, Needle, Ryan Brent, Baik, Lloyd, Yang, Cathryn, Shi, Jiejun, Kwak, Jin Hee, Ting, Kang, Zhang, Xinli, Soo, Chia
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206096/
https://ncbi.nlm.nih.gov/pubmed/31582804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0427-1
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