ATF3 promotes erastin-induced ferroptosis by suppressing system Xc(–)

The amino acid antiporter system Xc(−) is important for the synthesis of glutathione (GSH) that functions to prevent lipid peroxidation and protect cells from nonapoptotic, iron-dependent death (i.e., ferroptosis). While the activity of system Xc(−) often positively correlates with the expression le...

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Pubblicato in:Cell Death Differ
Autori principali: Wang, Liyuan, Liu, Yichen, Du, Tingting, Yang, Heng, Lei, Lei, Guo, Mengqi, Ding, Han-Fei, Zhang, Junran, Wang, Hongbo, Chen, Xiaoguang, Yan, Chunhong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206049/
https://ncbi.nlm.nih.gov/pubmed/31273299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0380-z
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