Haploinsufficiency of GCP4 induces autophagy and leads to photoreceptor degeneration due to defective spindle assembly in retina

Retinopathy, owing to damage to the retina, often causes vision impairment, and the underlying molecular mechanisms are largely unknown. Using a gene targeting strategy, we generated mice with the essential gene Tubgcp4 knocked out. Homozygous mutation of Tubgcp4 resulted in early embryonic lethalit...

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Detaylı Bibliyografya
Yayımlandı:Cell Death Differ
Asıl Yazarlar: Li, Zhigang, Li, Huirong, Xu, Xu, Wang, Lingling, Liu, Bo, Zheng, Weixin, Lian, Lili, Song, Ying, Xia, Xizhong, Hou, Ling, Cheng, Hanhua, Zhou, Rongjia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206048/
https://ncbi.nlm.nih.gov/pubmed/31209365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0371-0
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