Haploinsufficiency of GCP4 induces autophagy and leads to photoreceptor degeneration due to defective spindle assembly in retina

Retinopathy, owing to damage to the retina, often causes vision impairment, and the underlying molecular mechanisms are largely unknown. Using a gene targeting strategy, we generated mice with the essential gene Tubgcp4 knocked out. Homozygous mutation of Tubgcp4 resulted in early embryonic lethalit...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Differ
Egile Nagusiak: Li, Zhigang, Li, Huirong, Xu, Xu, Wang, Lingling, Liu, Bo, Zheng, Weixin, Lian, Lili, Song, Ying, Xia, Xizhong, Hou, Ling, Cheng, Hanhua, Zhou, Rongjia
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206048/
https://ncbi.nlm.nih.gov/pubmed/31209365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0371-0
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