Haploinsufficiency of GCP4 induces autophagy and leads to photoreceptor degeneration due to defective spindle assembly in retina

Retinopathy, owing to damage to the retina, often causes vision impairment, and the underlying molecular mechanisms are largely unknown. Using a gene targeting strategy, we generated mice with the essential gene Tubgcp4 knocked out. Homozygous mutation of Tubgcp4 resulted in early embryonic lethalit...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Li, Zhigang, Li, Huirong, Xu, Xu, Wang, Lingling, Liu, Bo, Zheng, Weixin, Lian, Lili, Song, Ying, Xia, Xizhong, Hou, Ling, Cheng, Hanhua, Zhou, Rongjia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206048/
https://ncbi.nlm.nih.gov/pubmed/31209365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0371-0
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