Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail

The mechanistic action of bromodomain-containing protein 4 (BRD4) in cancer motility, including epithelial-mesenchymal transition (EMT), remains largely undefined. We found that targeted inhibition of BRD4 reduces migration, invasion, in vivo growth of patient-derived xenograft (PDX), and lung colon...

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Bibliografiske detaljer
Udgivet i:Cell Death Differ
Main Authors: Lu, Linlin, Chen, Zhuojia, Lin, Xinyao, Tian, Lin, Su, Qiao, An, Panpan, Li, Wuguo, Wu, Yingmin, Du, Jun, Shan, Hong, Chiang, Cheng-Ming, Wang, Hongsheng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205888/
https://ncbi.nlm.nih.gov/pubmed/31114028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0353-2
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