Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis

Septic cardiomyopathy is a life-threatening organ dysfunction caused by sepsis. Ribonuclease 1 (RNase 1) belongs to a group of host-defense peptides that specifically cleave extracellular RNA (eRNA). The activity of RNase 1 is inhibited by ribonuclease-inhibitor 1 (RNH1). However, the role of RNase...

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Publicat a:JCI Insight
Autors principals: Zechendorf, Elisabeth, O’Riordan, Caroline E., Stiehler, Lara, Wischmeyer, Natalie, Chiazza, Fausto, Collotta, Debora, Denecke, Bernd, Ernst, Sabrina, Müller-Newen, Gerhard, Coldewey, Sina M., Wissuwa, Bianka, Collino, Massimo, Simon, Tim-Philipp, Schuerholz, Tobias, Stoppe, Christian, Marx, Gernot, Thiemermann, Christoph, Martin, Lukas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205433/
https://ncbi.nlm.nih.gov/pubmed/32213712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131571
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