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IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex
Recent studies in distinct preclinical tumor models have established the nucleotide synthesis enzyme inosine-5′-monophosphate dehydrogenase (IMPDH) as a viable target for antitumor therapy. IMPDH inhibitors have been used clinically for decades as safe and effective immunosuppressants. However, the...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7205253/ https://ncbi.nlm.nih.gov/pubmed/32271165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135071 |
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