IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex

Recent studies in distinct preclinical tumor models have established the nucleotide synthesis enzyme inosine-5′-monophosphate dehydrogenase (IMPDH) as a viable target for antitumor therapy. IMPDH inhibitors have been used clinically for decades as safe and effective immunosuppressants. However, the...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:JCI Insight
Hlavní autoři: Valvezan, Alexander J., McNamara, Molly C., Miller, Spencer K., Torrence, Margaret E., Asara, John M., Henske, Elizabeth P., Manning, Brendan D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205253/
https://ncbi.nlm.nih.gov/pubmed/32271165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135071
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky