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Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding

Resistance associated mutations (RAMs) threaten the long-term success of combination antiretroviral therapy (cART) outcomes for HIV-1 treatment. HIV-1 Integrase (IN) strand transfer inhibitors (INSTIs) have proven to be a viable option for highly specific HIV-1 therapy. The INSTI, Dolutegravir is re...

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書目詳細資料
發表在:PLoS One
Main Authors: Chitongo, Rumbidzai, Obasa, Adetayo Emmanuel, Mikasi, Sello Given, Jacobs, Graeme Brendon, Cloete, Ruben
格式: Artigo
語言:Inglês
出版: Public Library of Science 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205217/
https://ncbi.nlm.nih.gov/pubmed/32379830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223464
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