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Targeting the Small GTPase Superfamily through Their Regulatory Proteins

The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches essential for numerous cellular processes. Mutations or dysregulation of these proteins are associated with many diseases, but unsuccessful attempts to target the small GTPases directly have resulted in them being classed...

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Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Gray, Janine L., von Delft, Frank, Brennan, Paul E.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204875/
https://ncbi.nlm.nih.gov/pubmed/30869179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201900585
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