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Functional and mechanistic advantage of the use of a bifunctional anti-PD-L1/IL-15 superagonist

BACKGROUND: Anti(α)-programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) monotherapy fails to provide durable clinical benefit for most patients with carcinoma. Recent studies suggested that strategies to reduce immunosuppressive cells, promote systemic T-cell responses and lymphocyte tr...

詳細記述

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書誌詳細
出版年:J Immunother Cancer
主要な著者: Knudson, Karin M, Hicks, Kristin C, Ozawa, Yohei, Schlom, Jeffrey, Gameiro, Sofia R
フォーマット: Artigo
言語:Inglês
出版事項: BMJ Publishing Group 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204804/
https://ncbi.nlm.nih.gov/pubmed/32303618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000493
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