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Cooperative Immune-Mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL15 Superagonist, and a Cancer Vaccine Effectively Synergize as a Novel Cancer Therapy

PURPOSE: Immunotherapy has demonstrated clinical efficacy in subsets of patients with solid carcinomas. Multimodal therapies using agents that can affect different arms of the immune system and/or tumor microenvironment (TME) might increase clinical responses. EXPERIMENTAL DESIGN: We demonstrate tha...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Hicks, Kristin C., Knudson, Karin M., Lee, Karin L., Hamilton, Duane H., Hodge, James W., Figg, William D., Ordentlich, Peter, Jones, Frank R., Rabizadeh, Shahrooz, Soon-Shiong, Patrick, Schlom, Jeffrey, Gameiro, Sofia R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274944/
https://ncbi.nlm.nih.gov/pubmed/31645354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0727
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