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Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo

Chikungunya virus (CHIKV) is an important arthritogenic human pathogen that is already circulating in both hemispheres. In the present study, we substituted VLoop, located on the surface of nsP2, by other amino acid sequences. These modifications had deleterious effects on viral nuclear functions an...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Meshram, Chetan D., Lukash, Tetyana, Phillips, Aaron, Akhrymuk, Ivan, Frolova, Elena I., Frolov, Ilya
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204530/
https://ncbi.nlm.nih.gov/pubmed/31163352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2019.05.016
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