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Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo
Chikungunya virus (CHIKV) is an important arthritogenic human pathogen that is already circulating in both hemispheres. In the present study, we substituted VLoop, located on the surface of nsP2, by other amino acid sequences. These modifications had deleterious effects on viral nuclear functions an...
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| Опубликовано в: : | Virology |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7204530/ https://ncbi.nlm.nih.gov/pubmed/31163352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2019.05.016 |
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