IRE1α inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model

BACKGROUND: Inhibition of inositol-requiring enzyme-1 alpha (IRE1α), one of the sensor signaling proteins associated with endoplasmic reticulum (ER) stress, has been shown to alleviate brain injury and improve neurological behavior in a neonatal hypoxic-ischemic encephalopathy (HIE) rat model. Howev...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Neuroinflammation
Auteurs principaux: Huang, Juan, Lu, Weitian, Doycheva, Desislava Met, Gamdzyk, Marcin, Hu, Xiao, Liu, Rui, Zhang, John H., Tang, Jiping
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203836/
https://ncbi.nlm.nih.gov/pubmed/32375838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01796-3
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires