IRE1α inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model

BACKGROUND: Inhibition of inositol-requiring enzyme-1 alpha (IRE1α), one of the sensor signaling proteins associated with endoplasmic reticulum (ER) stress, has been shown to alleviate brain injury and improve neurological behavior in a neonatal hypoxic-ischemic encephalopathy (HIE) rat model. Howev...

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Publicat a:J Neuroinflammation
Autors principals: Huang, Juan, Lu, Weitian, Doycheva, Desislava Met, Gamdzyk, Marcin, Hu, Xiao, Liu, Rui, Zhang, John H., Tang, Jiping
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203836/
https://ncbi.nlm.nih.gov/pubmed/32375838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01796-3
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