Teriflunomide Does Not Change Dynamics of Nadph Oxidase Activation and Neuronal Dysfunction During Neuroinflammation

The multiple sclerosis therapeutic teriflunomide is known to block the de novo synthesis of pyrimidine in mitochondria by inhibiting the enzyme dihydroorotate-dehydrogenase (DHODH). The metabolic processes of oxidative phosphorylation and glycolysis are further possible downstream targets. In health...

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Опубликовано в: :Front Mol Biosci
Главные авторы: Mothes, Ronja, Ulbricht, Carolin, Leben, Ruth, Günther, Robert, Hauser, Anja E., Radbruch, Helena, Niesner, Raluca
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Molecular Biosciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203781/
https://ncbi.nlm.nih.gov/pubmed/32426367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00062
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