Teriflunomide Does Not Change Dynamics of Nadph Oxidase Activation and Neuronal Dysfunction During Neuroinflammation

The multiple sclerosis therapeutic teriflunomide is known to block the de novo synthesis of pyrimidine in mitochondria by inhibiting the enzyme dihydroorotate-dehydrogenase (DHODH). The metabolic processes of oxidative phosphorylation and glycolysis are further possible downstream targets. In health...

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Bibliographic Details
Published in:Front Mol Biosci
Main Authors: Mothes, Ronja, Ulbricht, Carolin, Leben, Ruth, Günther, Robert, Hauser, Anja E., Radbruch, Helena, Niesner, Raluca
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Molecular Biosciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203781/
https://ncbi.nlm.nih.gov/pubmed/32426367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00062
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