Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology

Genetic disruption or short-term pharmacological inhibition of MALT1 protease is effective in several preclinical models of autoimmunity and B cell malignancies. Despite these protective effects, the severe reduction in regulatory T cells (Tregs) and the associated IPEX-like pathology occurring upon...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Martin, Kea, Junker, Ursula, Tritto, Elaine, Sutter, Esther, Rubic-Schneider, Tina, Morgan, Hannah, Niwa, Satoru, Li, Jianping, Schlapbach, Achim, Walker, Dana, Bigaud, Marc, Beerli, Christian, Littlewood-Evans, Amanda, Rudolph, Bettina, Laisney, Marc, Ledieu, David, Beltz, Karen, Quancard, Jean, Bornancin, Frédéric, Zamurovic Ribrioux, Natasa, Calzascia, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203682/
https://ncbi.nlm.nih.gov/pubmed/32425939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00745
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