Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell–Mediated Autoimmunity

The paracaspase Malt1 is a key regulator of canonical NF-κB activation downstream of multiple receptors in both immune and nonimmune cells. Genetic disruption of Malt1 protease function in mice and MALT1 mutations in humans results in reduced regulatory T cells and a progressive multiorgan inflammat...

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Udgivet i:J Immunol
Main Authors: Martin, Kea, Touil, Ratiba, Kolb, Yeter, Cvijetic, Grozdan, Murakami, Kiichi, Israel, Laura, Duraes, Fernanda, Buffet, David, Glück, Anton, Niwa, Satoru, Bigaud, Marc, Junt, Tobias, Zamurovic, Natasa, Smith, Philip, McCoy, Kathy D., Ohashi, Pamela S., Bornancin, Frédéric, Calzascia, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: AAI 2019
Fag:
Autoimmunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859376/
https://ncbi.nlm.nih.gov/pubmed/31659015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900327
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