A Broad Spectrum Chemokine Inhibitor Prevents Preterm Labor but Not Microbial Invasion of the Amniotic Cavity or Neonatal Morbidity in a Non-human Primate Model

Leukocyte activation within the chorioamniotic membranes is strongly associated with inflammation and preterm labor (PTL). We hypothesized that prophylaxis with a broad-spectrum chemokine inhibitor (BSCI) would downregulate the inflammatory microenvironment induced by Group B Streptococcus (GBS, Str...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Coleman, Michelle, Orvis, Austyn, Wu, Tsung-Yen, Dacanay, Matthew, Merillat, Sean, Ogle, Jason, Baldessari, Audrey, Kretzer, Nicole M., Munson, Jeff, Boros-Rausch, Adam J., Shynlova, Oksana, Lye, Stephen, Rajagopal, Lakshmi, Adams Waldorf, Kristina M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203489/
https://ncbi.nlm.nih.gov/pubmed/32425945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00770
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