Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1

The transporter Multidrug Resistance Protein 1 (MRP1, ABCC1) is implicated in multidrug resistant (MDR) phenotype of cancer cells. Glutathione (GSH) plays a key role in MRP1 transport activities. In addition, a ligand-stimulated GSH transport which triggers the death of cells overexpressing MRP1, by...

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Vydáno v:Sci Rep
Hlavní autoři: Nasr, Rachad, Lorendeau, Doriane, Khonkarn, Ruttiros, Dury, Lauriane, Pérès, Basile, Boumendjel, Ahcène, Cortay, Jean-Claude, Falson, Pierre, Chaptal, Vincent, Baubichon-Cortay, Hélène
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203140/
https://ncbi.nlm.nih.gov/pubmed/32377003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64400-x
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