Activation of GPCR-Gαi signaling increases keratinocyte proliferation and reduces differentiation, leading to epidermal hyperplasia

G-protein-coupled receptors (GPCRs) and their associated heterotrimeric G proteins impinge on pathways that control epithelial cell self-renewal and differentiation. While it is known that Gαs signaling regulates skin homeostasis in vivo, the role of GPCR-coupled Gαi proteins in the skin is unclear....

Full description

Saved in:
Bibliographic Details
Published in:J Invest Dermatol
Main Authors: Pedro, M. Pilar, Parra, Natalia Salinas, Gutkind, J. Silvio, Iglesias-Bartolome, Ramiro
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202966/
https://ncbi.nlm.nih.gov/pubmed/31707029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2019.10.012
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items