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Activation of GPCR-Gαi signaling increases keratinocyte proliferation and reduces differentiation, leading to epidermal hyperplasia

G-protein-coupled receptors (GPCRs) and their associated heterotrimeric G proteins impinge on pathways that control epithelial cell self-renewal and differentiation. While it is known that Gαs signaling regulates skin homeostasis in vivo, the role of GPCR-coupled Gαi proteins in the skin is unclear....

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Bibliografische gegevens
Gepubliceerd in:J Invest Dermatol
Hoofdauteurs: Pedro, M. Pilar, Parra, Natalia Salinas, Gutkind, J. Silvio, Iglesias-Bartolome, Ramiro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202966/
https://ncbi.nlm.nih.gov/pubmed/31707029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2019.10.012
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