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Valid post-clustering differential analysis for single-cell RNA-Seq

Single-cell computational pipelines involve two critical steps: organizing cells (clustering) and identifying the markers driving this organization (differential expression analysis). State-of-the-art pipelines perform differential analysis after clustering on the same dataset. We observe that becau...

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Publicat a:Cell Syst
Autors principals: Zhang, Jesse M., Kamath, Govinda M., Tse, David N.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202736/
https://ncbi.nlm.nih.gov/pubmed/31521605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.07.012
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